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KMID : 0377619750280050507
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Korean Jungang Medical Journal
1975 Volume.28 No. 5 p.507 ~ p.511
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An Electron Microscopic Study of the Chages of the llepatocyte of Aconite Treated Rats
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Abstract
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Author´s previous two reports indicate that aconite preparation has a significant effect on accelerating blood alcohol clearance rate; however, its mode of action
has remained uncertain.
Author presumed that, of the two major pathways of alcohol metabolism, increased MEOS activity rather than ADH pathway would be responsible for this effect.
This is a study of the effect of aconite preparation on the morphological chan￢ges of rat liver cells by electron microscopy.
0.2 gm of specially detoxified aconite preparation was given to the rat three times each at four hour interval.
The liver.specimen was obtained one hour following the last dosage. Findings are summarized as follows;
1) Aconite treated liver cell showed that while rER were decreased proliferation: of sER-was significantly increased, which was considered as a reliable indicator of indreased MEOS activity in the liver cell. GERL and Golgi complex were also significantly proliferated indicating a rise in secretory activity of the liver cells.
2) Signs of a mild degree of degenerative changes of organoles were observed; ie, destruction of ribosome, fragmentation of rER, and changes of mitochondriae (decrease and deformity of cristae, decreased density due to swelling, and increased mitochodrial granule), however, these changes were not considered as a sign of serious cell damage.
3) Though lysosome was slightly increased as a reactive change following the above stated degenerative change, autophagic vacuole was not increased indicating the phenomenone of sequestration had not taken place yet. This is largely due to the short time interval between the last dosage given and the specimen obtained.
In summarizing the above findings, aconite treated animals showed significantly increased MEOS activity resulting from increased proliferation of sER, and it became a contributing factor in accelerating blood alcohol clearance rate.
Lastly, since sER is known to have many vitally important functions, the claims, made by herb medicine, that aconite is highly effective in controlling various clinical syndromes would be worth looking into.
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